If you’re thinking about upgrading your existing Active Directory Forest and Domain to Windows 2008 R2 you need to consider what applications you currently have running. There have been a number of issues relating to deploying Windows 2008 R2 Domains Controllers.
I was looking over on MS Support and noticed that OCS 2007, OCS 2007 R2 and LCS are now supported on Windows 2008 R2 Domains. The trick of it though is if you already have OCS deployed you will need to rerun the forest prep utility. For some reason when deploying the R2 schema and promoting to a DC the OCS schema information gets removed.
How odd but at least the fix is simple. So in the event you have OCS or LCS deployed and decide to move to Windows 2008 R2 AD keep in mind that you will need to rerun the the forestprep for OCS or use the Lcscmd command “Lcscmd.exe /forest /action:ForestPrep” which will work for LCS or OCS.
For more information see the following articles:
Office Communications Server 2007 R2, OCS 2007 or LCS 2005 does not work correctly after you upgrade to Windows Server 2008 R2
and
Supportability is available for Office Communications Server 2007 R2 member server role on a Windows Server 2008 R2 operating system